12/19/2023 0 Comments Antibody repertoire gestationOf the SCID subtypes, the proportion of SCID with B cell deficiencies was highly represented in our cohort. 8.7% of our SCID Moroccan cohort had T cell numbers higher than 500 cells/μ L. 5.7% of our SCID Moroccan cohort had T cell numbers in the range between 300 and 500 cells/μ L. Unexpectedly, significantly higher T cell counts were detected in some patients with a confirmed clinical diagnosis and family history of SCID. As expected, T cell count was less than 300 cells/μ L in most patients with SCID (85.5%). Results of peripheral blood T, B, and NK lymphocyte subpopulation counts were measured by flow cytometry for each SCID subtype. Thirty-five SCID confirmed patients were selected in the period between 20 and compared with non-PID patients. The objective of this cross-sectional retrospective study was to analyze the lymphocyte subpopulation counts along with clinical manifestations within a Moroccan cohort diagnosed as … SCID compared to children diagnosed with non-PID diseases. Notwithstanding, the heterogeneity of lymphocyte count presentation makes the diagnosis of SCID a significant challenge. Typically, the initial consideration of SCID is made based on low lymphocyte counts. The early diagnosis of SCID improves the prognosis. It is characterized by a serious abnormality of the cellular and sometimes humoral system due to a deficiency in development of T cells, B cells and/or NK cells. Keywords: Autoimmune disorders, methylenetetrahydrofolate reductase polymorphisms, pregnancy loss, miscarriage, chemical pregnancy, blighted ovumĪuthors: El Allam, Aicha | El Fakihi, Sara | Tahoune, Hicham | Sahmoudi, Karima | Bousserhane, Houria | Bakri, Youssef | El Hafidi, Naima | Seghrouchni, FouadĪbstract: Severe combined immunodeficiency (SCID) is a form of primary immunodeficiency disease (PID). The clinical findings seem to be more complicated in patients with gravidity ⩾ 5. CONCLUSIONS: PL rate before gw22 among singleton pregnancies with AD and/or MTHFR polymorphisms was 35.8%. Gravidity ⩽ 4 versus those with gravidity ⩾ 5 had statistically significant differences in BOI (p < 0.001). The rate of Pre-Prenatal Screening Period fetal losses (CP + BO + gw ⩽ 10 fetal losses + EP + TD) were 84.8%, 75.9%, and 77.8% in AD, MTHFR, and AD + MTHFR, respectively (p = 0.264). Obstetric histories were compared using Beksac Obstetrics Index (BOI): /gravida. PLs were classified into subgroups: a) … Chemical Pregnancy(CP), b) Blighted Ovum(BO), c) gw ⩽ 10, d) gw11–14 e) gw15–22, f) Ectopic Pregnancy(EP), g) Trophoblastic Disease(TD). METHODS: Totally, 1108 singleton pregnancies in 243 women were categorized as: 1) 148 pregnancies in 33 patients with AD, 2) 316 pregnancies in 66 patients with MTHFR polymorphisms, 3) 644 pregnancies in 144 patients with AD + MTHFR polymorphisms. OBJECTIVE: To evaluate singleton PLs before gestational week (gw) 22 among patients with AD and MTHFR polymorphisms. Authors: Cagan, Murat | Okuducu, Ummuhan | Donmez, Hanife Guler | Beksac, Mehmet SinanĪbstract: BACKGROUND: The rates of pregnancy losses (PLs) are increased by maternal risk factors such as autoimmune disorders (AD) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms.
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